Remission From Behavioral Dysregulation in a Child With PTSD After Receiving Procedural Ketamine

Abstract Ketamine, an N-methyl-D-aspartate–type glutamate receptor antagonist, has long been used for anesthesia and has recently been investigated for its rapid antidepressant effects in adults with treatment-resistant depression and posttraumatic stress disorder (PTSD). We report a case of a child with PTSD and episodes of severe aggression and emotional dysregulation that were refractory to multiple …

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Ketamine research reports 75% success rate in treatment of long-term depression

Researchers looking into the use of ketamine say they have had a 75 per cent success rate in using it to treat long-term depression. “The results are startling,” says Melbourne University neuroscientist Associate Professor Graham Barrett, who has been studying depression for 30 years. “They’re not 100 per cent, there are people who don’t respond …

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Subanesthetic ketamine infusions for the treatment of children and adolescents with chronic pain: a longitudinal study

Background Chronic pain is common in children and adolescents and is often associated with severe functional disability and mood disorders. The pharmacological treatment of chronic pain in children and adolescents can be challenging, ineffective, and is mostly based on expert opinions and consensus. Ketamine, an N-methyl-D-aspartate receptor antagonist, has been used as an adjuvant for …

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How much ketamine is the right dosage for Treatment Resistant Depression?

Abstract Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg over 40 min). However, the optimal antidepressant dose remains unknown. We aimed to compare to active placebo the rapid acting antidepressant properties of a …

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Ketamine for Social Anxiety Disorder: A Randomized, Placebo-Controlled Crossover Trial

‘- Jerome H Taylor, Angeli Landeros-Weisenberger, Catherine Coughlin, Jilian Mulqueen, Jessica A Johnson, Daniel Gabriel, Margot O Reed, Ewgeni Jakubovski and Michael H Bloch Abstract Many patients with social anxiety disorder (SAD) experience inadequate symptom relief from available treatments. Ketamine is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with a potentially novel mechanism of action for the …

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If You Are Fighting Depression, Consider Ketamine

Ketamine is a drug that is completely unique, and when it comes to treating depression, the results have been so good, it’s shocked many in psychiatry. “This is a game-changer,” Dr. John Krystal, chief psychiatrist at Yale Medicine, told Medical Xpress. “When you take ketamine, it triggers reactions in your cortex that enable brain connections …

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Emotional Scars Of PTSD And How Ketamine Can Help

It would be wonderful if life was a fairy tale and we all lived happily ever after. Unfortunately, the reality is that 7 in 10 people in America alone have experienced or witnessed a traumatic event at some point in their lives. Of those people, 20% of them will go on to experience PTSD. What …

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Your Guide to Treating CRPS with Ketamine

One of the most frustrating things about CRPS is that it’s not a widely understood pain condition. The International Neuromodulation Society explains that complex regional pain syndrome has been a challenge to treat historically. The main reason being that physicians can’t find an apparent cause for the degree of pain their patients are experiencing. As …

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Can Ketamine Therapy Help College Students Suffering from Anxiety?

College students across the United States are suffering from anxiety at staggering rates. More and more young adults are having difficulty keeping up with their studies while dealing with their own internal struggles. Anxiety disorder exists on a spectrum with some individuals suffering from such severe cases that it seems like everything becomes nearly impossible …

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CRPS / RSD: How Ketamine Treatment Modulates the Glutamate System

Have you recently been diagnosed with CRPS? Gary W. Jay, MD explains that CRPS (complex regional pain syndrome) is a “heterogeneous group of disorders that generally develop after trauma to soft tissue but also may develop after visceral diseases or nerve lesions, or rarely without an obvious antecedent event.” He further indicates that this neurologic …

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