How Fast Does Ketamine Work for Anxiety?

Medical Reviewer: Nima A. Fahimian, MD

Author:

Ben Spielberg, M.S., Ph.D. Candidate

Published:

Are you exhausted by constant dread, uneasiness, and sleep problems? It seems that everyone experiences anxiety these days, from simple daily stress to more serious mental health issues. It is entirely natural to feel worried or nervous in situations such as giving a speech in front of a large audience or waiting for your medical test results. However, anxiety disorders involve excessive apprehension that interferes with daily life and well-being. 

Anyone who’s been dealing with anxiety for a long time knows how challenging it is to handle that constant feeling of dread, restlessness, trouble sleeping, and just feeling drained all the time. While there are many medications for anxiety, studies show that about half of those who undergo treatment for generalized anxiety disorder (GAD) don’t respond to therapy and experience no improvement in anxiety symptoms. 

When other anxiety treatments fall short, ketamine offers a solution. Ketamine therapy for anxiety at Bespoke Treatment clinics in Nevada and California is a promising alternative for individuals with “treatment-resistant” anxiety. 

Ketamine Therapy: What It Is and How It Works?

Ketamine was initially developed as an anesthetic, but it is now commonly recognized for its therapeutic use in the treatment of mental health challenges such as depression, PTSD, and anxiety. Unlike traditional therapies, such as SSRIs, which can take weeks or even months to show symptom improvements, ketamine acts within hours by targeting glutamate. This neurotransmitter supports brain plasticity, mood, and cognitive flexibility. Ketamine works on NMDA receptors in the brain to quickly increase glutamate levels. This helps the brain adapt swiftly and form new, healthier connections. Many patients feel relief after their first session; the full benefits usually come after several treatments.

How Ketamine Therapy Reduces Anxiety and Improves Mental Health 

Ketamine is different from other anti-anxiety drugs because instead of simply increasing serotonin or dopamine, ketamine targets the brain’s NMDA receptors to produce a glutamate explosion. When glutamate levels are balanced, your brain works smoothly. But if there’s too much or too little, it can lead to mental health issues like anxiety, depression, and PTSD. Ketamine works by resetting and balancing glutamate levels. This surge in glutamate allows neuroplasticity, rewiring your brain and helping form new, healthier neural connections. The disruption in negative thinking patterns will enable you to form new neural pathways, which quickly relieve symptoms of anxiety and depression. Ketamine also creates an open critical period for treatment, in which the brain is more flexible and open to modification. 

Only a one-time ketamine infusion can help reduce panic, irritability, and various anxiety symptoms in people with GAD and social anxiety disorder, according to research. 

Furthermore, studies show that ketamine slows over-activity in the amygdala, the brain’s fear center that triggers anxiety responses. A survey by Ansara (2020) found that giving ketamine reduced the interaction between the amygdala and hippocampus. This suggests that ketamine might help reduce negative thinking patterns often found in depression, which could also be beneficial for anxiety disorders.

By increasing your brain’s neuroplasticity and rewiring your brain, ketamine disrupts problematic or harmful thought patterns. It allows you to create emotional distance from habitual anxious thinking.

In short, by calming the hyper-stress response, ketamine allows you to regain control of your emotions, establishing a sense of calmness, clarity, and resilience.

How Quickly Does Ketamine Work for Anxiety? 

Perhaps the most astounding aspect of ketamine treatment is its speed. Ketamine alleviates anxiety symptoms in as little as two hours after treatment.

Patients typically experience a considerable reduction in their level of anxiety after just one session, with the effects of ketamine persisting for days or weeks. For long-term benefits, a series of ketamine treatments is typically recommended, with periodic maintenance treatments.

However, how quickly ketamine works for anxiety varies depending on how it is administered.

Ketamine Therapy Methods: How It’s Administered

At Bespoke Treatment, we offer the following ketamine therapy options:

Ketamine intravenous (IV) infusions

This is the fastest and strongest method where ketamine is administered directly into the bloodstream.

Spravato Esketamine Nasal Spray  

This is an FDA-approved nasal spray for treatment-resistant depression and anxiety, with results in 24 hours. 

Ketamine-assisted psychotherapy.

At Bespoke Treatment, we combine ketamine with therapy sessions to enhance emotional processing and support long-term healing. 

Start Your Journey to Relief Today with Ketamine Therapy at Bespoke Treatment 

At Bespoke Treatment, we understand that it can be upsetting and isolating to live with anxiety. 

Ketamine therapy is an emerging, breakthrough treatment for anxiety that brings instant relief that conventional treatments can’t. If you haven’t found success with traditional treatments such as antidepressant medications and talk therapy, contact us today and discover how ketamine can help you regain your sense of peace. 

Reviews

As someone who has struggled with depression for years, I was skeptical about trying alternative treatment options. However, the team at Bespoke Treatment made me feel comfortable and supported throughout the entire process. Not only did their TMS therapy provide significant relief for my depression symptoms, but I also had a positive experience with their ketamine therapy. The staff was incredibly knowledgeable and took the time to answer all of my questions and address any concerns I had.

I can't recommend this place enough. I had an incredible experience with the treatment I received here. From the administrative staff to the medical team, I really appreciated the outstanding care and attention I received and always felt listened to. There was never any sense of rushing or a "one size fits all" approach, which is sadly very much the norm elsewhere. I highly recommend coming here for the excellent quality of services, professionalism, and warmth that are so important when you're needing mental health treatment.

TMS was amazing for me . I loved my treatments , the doctors, the staff as well as the office itself. Its an amazing place to go for your wellbeing . Everyone is super nice, kind and extremely professional. The place is very easy to get to with available parking. Basically no stress. I felt very comfortable with my technician and all his knowledge about TMS . I also loved Dr. Fahimian . He is extremely educated and knowable in his field. His patience in taking his time to answer all my questions and concerns were highly appreciated.

I was severely depressed when starting treatment. I could not handle meds and had big hopes that TMS would work. It absolutely did wonders for lifting my depression. I have my life back. I have motivation to do things and energy to achieve goals. I really wasn’t sure if the TMS method would work, but it did and I am forever grateful. It even helped with my ruminating thoughts. I’m able to be in the moment and get back into doing things I enjoy. I highly recommend TMS to anyone who needs it.

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