Ketamine Therapy for ADHD: Does It Really Work?

Medical Reviewer: Nima A. Fahimian, MD

Author:

Ben Spielberg, M.S., Ph.D. Candidate

Published:

Those who experience attention-deficit/hyperactivity disorder (ADHD) know how impulsivity, lack of focus, forgetfulness, or difficulty with organization can complicate daily life and relationships. You may have tried medication and behavioral therapy, but still struggle day-to-day with ADHD symptoms or experience medication side effects. It is frustrating when ADHD treatment seems to help others but doesn’t work the same for you.

However, everyone’s different—what works for a friend or coworker might not work for you, and that’s okay. However, when standard treatments do not give you the relief you need, new options, such as ketamine therapy at Bespoke Treatment clinics, can provide hope.

Ketamine and Ketamine Therapy: What They Are and How They Work

Ketamine is a medication that has been administered therapeutically for decades. This dissociative anesthetic was initially used in the 1960s to numb pain during surgeries. However, ketamine has soon attracted interest as a treatment for mental health issues.

Ketamine does not heavily affect important functions like breathing and circulation. In low doses, it is now used to help with treatment-resistant depression, anxiety, and post-traumatic stress disorder (PTSD), especially when other treatments don’t work. Doctors also use ketamine to manage chronic pain. More recently, ketamine has shown promise for treating ADHD.

How Does Ketamine Affect the Brain?

Ketamine changes the chemical glutamate, the brain’s most common excitatory neurotransmitter. Glutamate helps nerve cells communicate, keeping the brain active and alert. Glutamate is essential in cognitive processes such as learning and memory. It also plays a big role in mood regulation and pain perception.

Ketamine stimulates the NMDA (N-methyl-D-aspartate) receptor, which releases glutamate, unlike most antidepressant medications that target serotonin. This process helps the brain adapt quickly and encourages neural activity and the growth of new and healthier neural connections. By triggering the surge of glutamate, ketamine can rapidly improve mood, reduce negative thoughts quickly, and ease symptoms of depression, anxiety, or trauma.

Many patients report noticeable relief within hours or days. However, you can expect to achieve full benefits after several ketamine therapy sessions.

Why Ketamine Therapy for ADHD?

Ketamine therapy is being researched as a potential treatment for ADHD due to its unique effect on the brain’s glutamate system. ADHD can significantly affect your work, relationships, and other aspects of everyday life.

While research is only just beginning, there are some findings from studies and clinical experience that suggest ketamine therapy can be a helpful treatment for ADHD, particularly for those who have not responded to conventional therapies.

Traditional ADHD medications primarily target dopamine and norepinephrine, which may not provide lasting relief for some individuals. However, ketamine supports neuroplasticity, or the brain’s ability to grow, adapt, and reorganize. As a result, ketamine therapy may improve attention, focus, and concentration, reduce impulsivity, and enhance emotional regulation, which are often challenging for individuals with ADHD. Additionally, ketamine helps treat coexisting conditions like anxiety and depression without relying on long-term medication or years in therapy.

Ketamine Therapy vs. Traditional ADHD Treatment

Unlike most ADHD treatments that take weeks before noticeable results, ketamine has proven to offer relief within hours of a single infusion. This rapid effect is especially helpful for people with ADHD who experience comorbid anxiety and depression, as the co-occurring conditions often reduce mental clarity and concentration.

Beyond immediate relief, ketamine also supports long-term brain health, making it a promising option for neurodivergent people who seek greater clarity, focus, and emotional stability.

What to Expect from Ketamine Therapy at Bespoke Treatment

At Bespoke Treatment, we offer a personalized, evidence-based ketamine treatment designed to deliver rapid and effective relief from depression, anxiety, PTSD, and now ADHD.

Your ADHD treatment begins with a comprehensive review of your medical and mental health history to see if ketamine therapy is right for you. Our trained team of psychiatrists, therapists, and nurses will develop a treatment plan tailored to your needs.

Ketamine therapy at Bespoke Treatment in Nevada and California typically involves eight IV ketamine infusions over four weeks, each lasting about 40 minutes, with the whole session taking around two hours to allow for preparation and recovery. Other ketamine options at Bespoke Treatment include Spravato esketamine nasal spray and at-home ketamine-assisted therapy under the virtual guidance of our clinicians.

At Bespoke Treatment, we understand that each mental health journey is distinct. Our cutting-edge clinics in Nevada and California are committed to assisting you in finding rapid relief from unwanted thoughts, alleviating symptoms of ADHD, anxiety, depression, and PTSD, and developing resilience for the future.

If you’re ready to take back control and experience lasting change, book your consultation today and take the first step towards feeling better.

Reviews

As someone who has struggled with depression for years, I was skeptical about trying alternative treatment options. However, the team at Bespoke Treatment made me feel comfortable and supported throughout the entire process. Not only did their TMS therapy provide significant relief for my depression symptoms, but I also had a positive experience with their ketamine therapy. The staff was incredibly knowledgeable and took the time to answer all of my questions and address any concerns I had.

I can't recommend this place enough. I had an incredible experience with the treatment I received here. From the administrative staff to the medical team, I really appreciated the outstanding care and attention I received and always felt listened to. There was never any sense of rushing or a "one size fits all" approach, which is sadly very much the norm elsewhere. I highly recommend coming here for the excellent quality of services, professionalism, and warmth that are so important when you're needing mental health treatment.

TMS was amazing for me . I loved my treatments , the doctors, the staff as well as the office itself. Its an amazing place to go for your wellbeing . Everyone is super nice, kind and extremely professional. The place is very easy to get to with available parking. Basically no stress. I felt very comfortable with my technician and all his knowledge about TMS . I also loved Dr. Fahimian . He is extremely educated and knowable in his field. His patience in taking his time to answer all my questions and concerns were highly appreciated.

I was severely depressed when starting treatment. I could not handle meds and had big hopes that TMS would work. It absolutely did wonders for lifting my depression. I have my life back. I have motivation to do things and energy to achieve goals. I really wasn’t sure if the TMS method would work, but it did and I am forever grateful. It even helped with my ruminating thoughts. I’m able to be in the moment and get back into doing things I enjoy. I highly recommend TMS to anyone who needs it.

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