CRPS / RSD: How Ketamine Treatment Modulates the Glutamate System

Have you recently been diagnosed with CRPS? Gary W. Jay, MD explains that CRPS (complex regional pain syndrome) is a “heterogeneous group of disorders that generally develop after trauma to soft tissue but also may develop after visceral diseases or nerve lesions, or rarely without an obvious antecedent event.” He further indicates that this neurologic …

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Subanesthetic ketamine infusions for the treatment of children and adolescents with chronic pain: a longitudinal study

Background Chronic pain is common in children and adolescents and is often associated with severe functional disability and mood disorders. The pharmacological treatment of chronic pain in children and adolescents can be challenging, ineffective, and is mostly based on expert opinions and consensus. Ketamine, an N-methyl-D-aspartate receptor antagonist, has been used as an adjuvant for …

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Why Are Suicide Rates Rising?

Humanity needs to have an uncomfortable conversation about suicide. It’s a growing problem in the West and one that we don’t give nearly enough attention. Around 800,000 people kill themselves every year, according to the World Health Organization. After car accidents, it’s the leading cause of death for people between ages 15 and 29. Clearly, …

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Population scale data reveals the antidepressant effects of ketamine

Abstract Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of eight million reports from the FDA Adverse Effect Reporting System. The results of the examination of population scale …

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Guidelines for Use of IV Ketamine Infusions for Acute Pain Management Released

The American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists have released consensus guidelines on the use of intravenous (IV) ketamine for the management of acute pain. “The use of ketamine for chronic pain has skyrocketed, and because it is an off-label use of a generic …

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What Does The Mental Effect Of Ketamine Feel Like?

It’s not unusual for individuals who haven’t experienced Ketamine treatments before to feel nervous, much like any other initial medical procedure. There may be questions, worries, and uncertainties regarding the potential variations in experiences. These feelings are completely legitimate since, similar to any treatment, Ketamine can yield diverse results due to factors such as dosage …

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Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Abstract Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with treatment-resistant depression, which may be prolonged by repeated administration. The purpose of this study was to evaluate the antidepressant effects of a single ketamine infusion, a series of repeated ketamine infusions, and prolongation of response with maintenance …

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How Revolutionary is Ketamine for Treating Depression and Anxiety?

Researchers are having a difficult time developing new classes of medicine to treat mood disorders such as depression, anxiety, PTSD and pain associated with these conditions. Years ago, psychiatrists treated these mood disorders with medications that blocked monoamine receptors and monoamine transporters. However, these medicines produced adverse side effects, and some failed to work effectively. …

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Ketamine may help treat migraine pain unresponsive to other therapies

Ketamine, a medication commonly used for pain relief and increasingly used for depression, may help alleviate migraine pain in patients who have not been helped by other treatments, suggests a study being presented at the ANESTHESIOLOGY® 2017 annual meeting. The study of 61 patients found that almost 75 percent experienced an improvement in their migraine intensity …

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Suicides Are At An All-Time High. Is There Anything We Can Do?

The high suicide rate in the United States is undoubtedly a public health crisis. It may be happening so slowly that many health officials don’t notice, but the numbers don’t lie. According to the Center for Disease Control and Prevention, the number of people who died by suicide increased in 49 out of 50 American …

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