Could Spravato or Ketamine Therapy Work for You?

Medical Reviewer: Nima A. Fahimian, MD

Author:

Ben Spielberg, M.S., Ph.D. Candidate

Published:

For individuals struggling with treatment-resistant depression or PTSD, Spravato (esketamine) and ketamine therapy offer hope when traditional treatments fall short. But how do you know if one of these innovative therapies is right for you? Below, we take a closer look at how they work and who benefits most to help you make an informed decision.

How Do Spravato and Ketamine Therapy Work?

Both Spravato and ketamine therapy target NMDA receptors in the brain, triggering the release of glutamate. This neurotransmitter plays a key role in forming new neural connections and improving communication between brain cells. By reshaping neural pathways, these treatments create opportunities for healing and lasting change.

Spravato, an FDA-approved nasal spray, isolates the S-ketamine molecule and is delivered in controlled doses. Meanwhile, ketamine therapy, administered intravenously (IV) or intramuscularly (IM), contains both R- and S-ketamine, offering a broader spectrum of action. While both are effective, they serve different purposes and patient profiles.

Who is a Good Candidate for Spravato or Ketamine Therapy?

Spravato and ketamine therapy are designed for individuals who have not found relief through traditional treatments like oral antidepressants or talk therapy. They may be particularly effective for:

  • Treatment-resistant depression
  • PTSD and other mood disorders
  • Severe or acute symptoms, such as suicidal ideation

Spravato is often recommended for those with moderate depression or for maintenance therapy, while ketamine infusions are better suited for patients with more severe symptoms requiring rapid relief.

Is It Safe?

While these treatments are generally safe, certain medical conditions may require additional evaluation. For example, individuals with uncontrolled hypertension, cardiac history, or elevated liver enzymes may need clearance before starting therapy. A thorough evaluation, like the one offered at Bespoke Treatment, ensures safety and suitability.

With Bespoke Treatment, both therapies are administered in controlled medical environments to minimize risks and maximize benefits. Every step of the way, our practitioners closely monitor each patient to ensure comfort and safety.

What to Expect During Treatment

Spravato sessions typically last about two hours, including post-treatment observation. On the other hand, ketamine infusions vary in length depending on the dose and patient response. Both treatments are introspective, allowing patients to process emotions and experiences in new ways. Follow-up therapy or counseling is often recommended to solidify the insights gained during these sessions.

It’s important to note that neither Spravato nor ketamine therapy is a one-size-fits-all solution. While many patients experience profound benefits, others may require a few sessions to determine if the treatment is effective for them. Providers typically recommend four initial sessions to evaluate progress.

At Bespoke Treatment, we specialize in tailoring treatment plans to each individual’s needs. Our goal is to empower patients to achieve lasting results and a renewed sense of well-being. Contact us today to learn more. Our caring and compassionate team is ready to help.

Reviews

As someone who has struggled with depression for years, I was skeptical about trying alternative treatment options. However, the team at Bespoke Treatment made me feel comfortable and supported throughout the entire process. Not only did their TMS therapy provide significant relief for my depression symptoms, but I also had a positive experience with their ketamine therapy. The staff was incredibly knowledgeable and took the time to answer all of my questions and address any concerns I had.

I can't recommend this place enough. I had an incredible experience with the treatment I received here. From the administrative staff to the medical team, I really appreciated the outstanding care and attention I received and always felt listened to. There was never any sense of rushing or a "one size fits all" approach, which is sadly very much the norm elsewhere. I highly recommend coming here for the excellent quality of services, professionalism, and warmth that are so important when you're needing mental health treatment.

TMS was amazing for me . I loved my treatments , the doctors, the staff as well as the office itself. Its an amazing place to go for your wellbeing . Everyone is super nice, kind and extremely professional. The place is very easy to get to with available parking. Basically no stress. I felt very comfortable with my technician and all his knowledge about TMS . I also loved Dr. Fahimian . He is extremely educated and knowable in his field. His patience in taking his time to answer all my questions and concerns were highly appreciated.

I was severely depressed when starting treatment. I could not handle meds and had big hopes that TMS would work. It absolutely did wonders for lifting my depression. I have my life back. I have motivation to do things and energy to achieve goals. I really wasn’t sure if the TMS method would work, but it did and I am forever grateful. It even helped with my ruminating thoughts. I’m able to be in the moment and get back into doing things I enjoy. I highly recommend TMS to anyone who needs it.

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