depression Archives - Page 3 of 5

How much ketamine is the right dosage for Treatment Resistant Depression?

September 23, 2024July 1, 2021

Abstract Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient antidepressant effects when administered intravenously (IV) at subanesthetic doses (0.5 mg/kg over 40 min). However, the optimal antidepressant dose remains unknown. We aimed to compare to active placebo the rapid acting antidepressant properties of a …

If You Are Fighting Depression, Consider Ketamine

September 27, 2024July 1, 2021

Ketamine is a drug that is completely unique, and when it comes to treating depression, the results have been so good, it’s shocked many in psychiatry. “This is a game-changer,” Dr. John Krystal, chief psychiatrist at Yale Medicine, told Medical Xpress. “When you take ketamine, it triggers reactions in your cortex that enable brain connections …

Experimental drug shows promise for treatment of postpartum depression

September 23, 2024July 1, 2021

An experimental drug touted as a breakthrough for treating severe postpartum depression is showing some promising results in a small clinical trial. Sage Therapeutics (SAGE), based in Cambridge, Mass., reported on Tuesday that 7 of the 10 women who took the drug in the trial experienced significant improvement in their depression within 60 hours of …

Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

September 25, 2024July 1, 2021

Abstract Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with treatment-resistant depression, which may be prolonged by repeated administration. The purpose of this study was to evaluate the antidepressant effects of a single ketamine infusion, a series of repeated ketamine infusions, and prolongation of response with maintenance …

Quantifying the Cost of Depression

September 23, 2024June 28, 2021

Key Findings Approximately 6-7% of full-time U.S. workers experienced major depression (MDD) within the past year. The total economic burden of MDD is now estimated to be $210.5 billion per year. For every dollar spent on MDD direct costs in 2010, an additional $1.90 was spent on MDD-related indirect costs. An important study reveals just …

How New Ketamine Drug Helps with Depression

September 23, 2024June 25, 2021

On March 5, 2019 the Food and Drug Administration (FDA) approved the first truly new medication for major depression in decades. The drug is a nasal spray called esketamine, derived from ketamine—an anesthetic that has made waves for its surprising antidepressant effect. Interestingly, studies from Yale research labs showed that the drug ketamine, which was widely used as …

New Hope for Depression – Time Magazine Cover Story

September 23, 2024June 25, 2021

At last count, about 12% of Americans took antidepressants. Global revenue for antidepressants was about $14.5 billion in 2014 and is projected to grow to nearly $17 billion over the next three years. Clinical depression affects 6.7% of U.S. adults, or about 16 million people, and a growing number of children and teenagers too. It’s …

Depression – Where Daily Pills Fail, Ketamine Therapy Can Work

September 23, 2024June 24, 2021

If you keep up with the news then chances are, you have heard about the exciting recent discoveries that have been made when it comes to ketamine therapy. This is one of those rare instances in which you should actually investigate the hype. Those who suffer from depression know how devastating and isolating it can …

5 Myths About Depression That You Need To Hear

September 23, 2024June 24, 2021

Depression is a condition that is poorly understood by the public. Major depressive disorder is widespread, one of the most prevalent mental health issues in this country. It affects an estimated 17.3 million residents including 8.7 percent of adult women and 5.3 percent of adult men. There is a stigmatism attached to depression that can keep …

How To Break The Endless Cycle of Failed Medication After Medication

September 25, 2024June 23, 2021

Imagine what it’s like to have depression impact all areas of your life. Think about carrying around a crippling burden that continues to grow a little more each day. Soon, it starts to manifest in different ways through lingering sadness, increased irritability, and anxious thinking until it completely wears you down. Depression is consuming, debilitating, …

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